Detail publikace

Tracing dsDNA Virus–Host Coevolution through Correlation of Their G-Quadruplex-Forming Sequences

BOHÁLOVÁ, N. CANTARA, A. BARTAS, M. KAURA, P. ŠŤASTNÝ, J. PEČINKA, P. FOJTA, M. BRÁZDA, V.

Originální název

Tracing dsDNA Virus–Host Coevolution through Correlation of Their G-Quadruplex-Forming Sequences

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

The importance of gene expression regulation in viruses based upon G-quadruplex may point to its potential utilization in therapeutic targeting. Here, we present analyses as to the occurrence of putative G-quadruplex-forming sequences (PQS) in all reference viral dsDNA genomes and evaluate their dependence on PQS occurrence in host organisms using the G4Hunter tool. PQS frequencies differ across host taxa without regard to GC content. The overlay of PQS with annotated regions reveals the localization of PQS in specific regions. While abundance in some, such as repeat regions, is shared by all groups, others are unique. There is abundance within introns of Eukaryota-infecting viruses, but depletion of PQS in introns of bacteria-infecting viruses. We reveal a significant positive correlation between PQS frequencies in dsDNA viruses and corresponding hosts from archaea, bacteria, and eukaryotes. A strong relationship between PQS in a virus and its host indicates their close coevolution and evolutionarily reciprocal mimicking of genome organization.

Klíčová slova

Bioinformatics; Coevolution; DsDNA; G-quadruplex; G4Hunter; Host; Virus

Autoři

BOHÁLOVÁ, N.; CANTARA, A.; BARTAS, M.; KAURA, P.; ŠŤASTNÝ, J.; PEČINKA, P.; FOJTA, M.; BRÁZDA, V.

Vydáno

1. 4. 2021

Nakladatel

MDPI

ISSN

1422-0067

Periodikum

International Journal of Molecular Sciences

Ročník

22

Číslo

7

Stát

Švýcarská konfederace

Strany od

1

Strany do

12

Strany počet

12

URL

https://www.mdpi.com/1422-0067/22/7/3433

Plný text v Digitální knihovně

http://hdl.handle.net/11012/200878

BibTex

@article{BUT171724,
  author="Natália {Bohálová} and Alessio {Cantara} and Martin {Bartas} and Patrik {Kaura} and Jiří {Šťastný} and Petr {Pečinka} and Miroslav {Fojta} and Václav {Brázda}",
  title="Tracing dsDNA Virus–Host Coevolution through Correlation of Their G-Quadruplex-Forming Sequences",
  journal="International Journal of Molecular Sciences",
  year="2021",
  volume="22",
  number="7",
  pages="1--12",
  doi="10.3390/ijms22073433",
  issn="1422-0067",
  url="https://www.mdpi.com/1422-0067/22/7/3433"
}