Detail publikace

Synergistic Effect of Chitosan and Selenium Nanoparticles on Biodegradation and Antibacterial Properties of Collagenous Scaffolds Designed for Infected Burn Wounds

DORAZILOVÁ, J. MUCHOVÁ, J. ŠMERKOVÁ, K. KOČIOVÁ, S. DIVIŠ, P. KOPEL, P. VESELÝ, R. PAVLIŇÁKOVÁ, V. ADAM, V. VOJTOVÁ, L.

Originální název

Synergistic Effect of Chitosan and Selenium Nanoparticles on Biodegradation and Antibacterial Properties of Collagenous Scaffolds Designed for Infected Burn Wounds

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

A highly porous scaffold is a desirable outcome in the field of tissue engineering. The porous structure mediates water-retaining properties that ensure good nutrient transportation as well as creates a suitable environment for cells. In this study, porous antibacterial collagenous scaffolds containing chitosan and selenium nanoparticles (SeNPs) as antibacterial agents were studied. The addition of antibacterial agents increased the application potential of the material for infected and chronic wounds. The morphology, swelling, biodegradation, and antibacterial activity of collagen-based scaffolds were characterized systematically to investigate the overall impact of the antibacterial additives. The additives visibly influenced the morphology, water retaining properties as well as the stability of the materials in the presence of collagenase enzymes. Even at concentrations as low as 5 ppm of SeNPs, modified polymeric scaffolds showed considerable inhibition activity towards Gram-positive bacterial strains such as Staphylococcus aureus and methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis in a dose-dependent manner.

Klíčová slova

tissue engineering; drug release; freeze-drying; collagen; chitosan; selenium nanoparticles; infected burn injuries; bacteria; Staphylococcus

Autoři

DORAZILOVÁ, J.; MUCHOVÁ, J.; ŠMERKOVÁ, K.; KOČIOVÁ, S.; DIVIŠ, P.; KOPEL, P.; VESELÝ, R.; PAVLIŇÁKOVÁ, V.; ADAM, V.; VOJTOVÁ, L.

Vydáno

5. 10. 2020

Nakladatel

MDPI

Místo

Basel

ISSN

2079-4991

Periodikum

Nanomaterials

Ročník

10

Číslo

10

Stát

Švýcarská konfederace

Strany od

1971

Strany do

1992

Strany počet

21

URL

https://www.mdpi.com/2079-4991/10/10/1971

Plný text v Digitální knihovně

http://hdl.handle.net/11012/195615

BibTex

@article{BUT165864,
  author="Jana {Matulová} and Johana {Muchová} and Kristýna {Šmerková} and Silvia {Kočiová} and Pavel {Diviš} and Pavel {Kopel} and Radek {Veselý} and Veronika {Pavliňáková} and Vojtěch {Adam} and Lucy {Vojtová}",
  title="Synergistic Effect of Chitosan and Selenium Nanoparticles on Biodegradation and Antibacterial Properties of Collagenous Scaffolds Designed for Infected Burn Wounds",
  journal="Nanomaterials",
  year="2020",
  volume="10",
  number="10",
  pages="1971--1992",
  doi="10.3390/nano10101971",
  issn="2079-4991",
  url="https://www.mdpi.com/2079-4991/10/10/1971"
}