Detail publikace

RAPID FABRICATION OF MICROEXTRACTION DEVICES FOR DIRECT DETERMINATION OF BASIC DRUGS IN DRIED BLOOD SPOTS

RYŠAVÁ, L. PŘIKRYL, J. DVOŘÁK, M. MALÁ, Z. KUBÁŇ, P.

Originální název

RAPID FABRICATION OF MICROEXTRACTION DEVICES FOR DIRECT DETERMINATION OF BASIC DRUGS IN DRIED BLOOD SPOTS

Typ

článek ve sborníku ve WoS nebo Scopus

Jazyk

angličtina

Originální abstrakt

A 3D-printed cutter was designed for rapid fabrication of supported liquid membrane (SLM) extraction devices compatible with injection system of commercial capillary electrophoresis (CE) instrument. Low cost and single use microextraction devices were fabricated from polypropylene micropipette tips with high precision (dimension variances ≤ 3% RSD). Practical applicability of the microextraction devices was examined by in-line coupling of SLM extractions to CE for direct analysis of four model basic drugs in dried blood spot extracts. Excellent repeatability of the hyphenated technique was achieved (RSD ≤ 7.6%), transfer of analytes across the SLM ranged from 23 to 73% and limits of detection were as low as 0.07 µg/mL.

Klíčová slova

capillary electrophoresis, 3D print cutter, blood spots

Autoři

RYŠAVÁ, L.; PŘIKRYL, J.; DVOŘÁK, M.; MALÁ, Z.; KUBÁŇ, P.

Vydáno

8. 10. 2018

ISBN

978-80-904959-5-1

Kniha

CECE 2018: 15th International Interdisciplinary Meeting on Bioanalysis

Strany od

257

Strany do

260

Strany počet

4

URL

http://www.ce-ce.org/user_uploads/program/CECE%202018%20Proceedings_WOS.pdf

BibTex

@inproceedings{BUT152127,
  author="Lenka {Ryšavá} and Miloš {Dvořák}",
  title="RAPID FABRICATION OF MICROEXTRACTION DEVICES FOR DIRECT DETERMINATION OF BASIC DRUGS IN DRIED BLOOD SPOTS",
  booktitle="CECE 2018: 15th International Interdisciplinary Meeting on Bioanalysis",
  year="2018",
  pages="257--260",
  isbn="978-80-904959-5-1",
  url="http://www.ce-ce.org/user_uploads/program/CECE%202018%20Proceedings_WOS.pdf"
}