Detail publikace

Improving stability of co-amorphous drug system with addition of PVP

TÜRKEOVÁ, I. ENEV, V. KLUČÁKOVÁ, M.

Originální název

Typ

článek ve sborníku ve WoS nebo Scopus

Jazyk

angličtina

Originální abstrakt

Approximately 90% of small molecular weight drug candidates under development have poor aqueous solubility.One of the most promising approaches in the development of drug delivery systems to improve the efficacy of new drugs is the conversion of a crystalline drug to its respective amorphous counterpart. In this case we tried used aminoacid as stabilizer and PVP6, 7. As drug we used Indomethacin - poorly water soluble BCS class II drug. Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) that reduces fever, pain and inflammation. We tried to prepare co-amorphous mixtures with aminoacid and polymer and will see that is working, is stable or not.

Klíčová slova

co-amorphous system, PVP, indomethacin, amorf form

Autoři

TÜRKEOVÁ, I.; ENEV, V.; KLUČÁKOVÁ, M.

Rok RIV

2015

Vydáno

3. 12. 2015

Nakladatel

Vysoké učení technické v Brně, Fakulta chemická

Místo

Brno

ISBN

978-80-214-5290-9

Kniha

Sborník abstraktů 3. prosince 2015 - Studentská konference Chemie je život

Edice

Číslo edice

Strany od

310

Strany do

316

Strany počet

BibTex

@inproceedings{BUT129222,
  author="Irena {Solná} and Vojtěch {Enev} and Martina {Klučáková}",
  title="Improving stability of co-amorphous drug
system with addition of PVP",
  booktitle="Sborník abstraktů 3. prosince 2015 - Studentská konference Chemie je život",
  year="2015",
  series="1",
  number="1",
  pages="310--316",
  publisher="Vysoké učení technické v Brně, Fakulta chemická",
  address="Brno",
  isbn="978-80-214-5290-9"
}