Detail publikace

Synthesis of some new N-glycosyl and 4-aryl-2-((1-(piperidin-1-ylmethyl)-1H-benzo[d] imidazol-2- yl)methyl)phthalazin-1(2H)-one

EL-SHAMY, I. BAKEER, H. AL-SHAMRANI, K. ABDEL-LATTIF, A. AL-SHEHRI, M.

Originální název

Typ

článek v časopise ve Scopus, Jsc

Jazyk

angličtina

Originální abstrakt

A series of 2-((1H-benzo[d]imidazol-2-yl)methyl)-4-arylphthalazin-1(2H)-one (3) and 2-((1-substituted- 1H-benzo[d]imidazol-2-yl)methyl)-4-arylphthalazin-1(2H)-one (4) were synthesized starting from 4-arylphthalazin- 1(2H)-one (1). Moreover, the N-glycosyl of 2-((1H-benzo[d]imidazol-2-yl)methyl)-4-arylphthalazin-1(2H)-one (5a,b) were synthesized by interaction of phthalazinone derivative (3) with acetobromo-alfa-D-glucose. Deacetylation of acetylated N-nucleosides 5a,b using ammonia solution in methanol afforded the corresponding deacetylatedNglycosyl 6a,b respectively. The structures of the synthesized compounds were confirmed by 1HNMR, 13CNMR, MS, IR spectroscopy and by elemental analysis.

Klíčová slova

N-glycosyl; phthalazinone; antimicrobial activity, Benzamidazole

Autoři

EL-SHAMY, I.; BAKEER, H.; AL-SHAMRANI, K.; ABDEL-LATTIF, A.; AL-SHEHRI, M.

Rok RIV

2014

Vydáno

1. 4. 2014

ISSN

1097-8135

Periodikum

Life Science Journal

Ročník

Číslo

Stát

Čínská lidová republika

Strany od

Strany do

Strany počet

BibTex

@article{BUT112296,
  author="Ibrahim E. {El-Shamy} and Hadeer M. {Bakeer} and Khalid M. {Al-Shamrani} and Abdelmohsen Moustafa {Abdellatif} and Mohammed M. {Al-Shehri}",
  title="Synthesis of some new N-glycosyl and 4-aryl-2-((1-(piperidin-1-ylmethyl)-1H-benzo[d] imidazol-2- yl)methyl)phthalazin-1(2H)-one",
  journal="Life Science Journal",
  year="2014",
  volume="11",
  number="4",
  pages="94--99",
  issn="1097-8135"
}