Detail předmětu
Biophysical Chemistry
FCH-MAA_BCHAk. rok: 2022/2023
The course focuses on the application of basic theoretical knowledge of physical chemistry to the biological systems. It represents a borderline course between physics, chemistry and biology, which allow obtaining molecular and structural perspective on biologically important and medically important pehnomena. Attention is drawn to an impact of the basic theoretical knowledge into analytical (advanced methods of study and interpretation of the structure and function of biopolymers) and application fields.
Jazyk výuky
angličtina
Počet kreditů
4
Garant předmětu
Zajišťuje ústav
Nabízen zahraničním studentům
Všech fakult
Osnovy výuky
- Introduction to biophysical chemistry (biophysical chemistry as a scientific discipline - history, classification, basic concepts and terminology, scope and topics; strategy of biophysical chemistry - building the biophysical models, role of estimates)
- Role of molecular interactions I (non-covalent interactions and their role in biology; interaction potential; covalent vs. non-covalent interactions; interactions involving charged, polar and non-polar molecules, van der Waals interactions)
- Role of molecular interactions II (H – bond; hydrophobic effect; pi – interactions; specific ion effects; coordinate bonds)
- Biological thermodynamics I (system & surroundings; application of the First and the Second laws of thermodynamics on living systems; energy transformation & distribution in biosphere)
- Biological thermodynamics II (entropy & disorder; entropy & isothermal systems; the Third law of thermodynamics; irreversibility & life; Gibbs energy)
- Bioenergetics (energy transformations & fate of ATP in organisms)
- Phase transitions in biological systems I (solubility of biomolecules; acid base dissociation; ampholytes & polyelectrolytes; buffers)
- Phase transitions in biological systems II (structure, stability & phase transitions of biopolymers)
- Binding equlibria (molecular recognition; effects involved in a receptor-substrate binding; thermodynamic models of binding equilibria; case study: oxygen binding by myoglobin and hemoglobin)
- Function and properties of biological membranes (membrane equilibria; function of biological membranes; structure, mechanic, electric and transport properties of biological membranes)
- Non-equilibrium thermodynamics (problems with describind living systems with equilibrium thermodynamics; stationary state)
- Biological kinetics I (thermodynamic vs. kinetic control of biological phenomena; biochemical reaction rate; reaction rate constant theory)
- Biological kinetics II (electron transfer - redox processes; proton transfer - acidobazic processes; protein denaturation and renaturation; enzyme kinetics; pharmacokinetics)
Elearning
eLearning: aktuální otevřený kurz
Zařazení předmětu ve studijních plánech
- Program NPAP_ENVI magisterský navazující 1 ročník, zimní semestr, volitelný
Typ (způsob) výuky
Elearning
eLearning: aktuální otevřený kurz